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an unusual or allergic reaction to tadalafil, other medicines, foods, dyes, or preservatives
Take this medicine by mouth with a glass of water. You may take this medicine with or without meals. The dose is usually taken 15 to 20 minutes before sexual activity. You should not take this dose more than once per day. Do not take your medicine more often than directed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
nitrates like amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin
certain drugs used for fungal or yeast infections, like fluconazole, itraconazole, ketoconazole, and voriconazole
certain drugs used for seizures like carbamazepine, phenytoin, and phenobarbital
macrolide antibiotics like clarithromycin, erythromycin, troleandomycin
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This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
If you notice any changes in your vision while taking this drug, call your doctor or health care professional as soon as possible. Stop using this medicine and call your health care provider right away if you have a loss of sight in one or both eyes.
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Using this medicine does not protect you or your partner against HIV infection the virus that causes AIDS or other sexually transmitted diseases.
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STAXYN is a prescription medicine used to treat erectile dysfunction ED in men.
STAXYN. Check out the pack. Check out the price.
Proven to help treat erectile dysfunction, prescription STAXYN is a tablet that dissolves on your tongue without liquid and comes in a sleek slide-pack.
Ask your doctor and pharmacist about the risks and benefits of STAXYN.
STAXYN is a prescription medicine used for the treatment of erectile dysfunction ED in men.
STAXYN can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. With a sudden drop in blood pressure, you could get dizzy, faint, or have a heart attack or stroke.
STAXYN contains phenylalanine, which can be harmful to people who have phenylketonuria.
Take any medications called nitrates often used to control chest pain, also known as angina, or if you use recreational drugs called poppers like amyl nitrate and butyl nitrate. Nitrates may cause abnormally low blood pressure and STAXYN may increase that risk.
Have been told by your healthcare provider not to have sexual activity because of health problems. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease.
Tell all your healthcare providers that you take STAXYN. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took STAXYN.
STAXYN does not protect a man or his partner from sexually transmitted diseases, including HIV.
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have heart problems such as angina, heart failure, irregular heartbeats, or have had a heart attack-ask your doctor if it is safe for you to have sexual activity
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Cialis ingredients are not the right choice for everybody. It s only your doctor who can confirm whether Cialis is the right choice for you or not. If you are allergic to any of the ingredients of Cialis it would be a good idea to stay away from this pill. Also inform your doctor if you suffer from problems like hypertension, liver or kidney problems or heart problems amongst other health conditions. Only if your healthcare provider deems that Cialis ingredients are safe for you will you be prescribed this medication.
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Cialis Tadalafil is an oral drug, used for treating male impotence, also known as men s erectile dysfunction. Cialis is a prescribed pill that is taken orally. It works in the body by increasing the supply of blood to the penis and its surrounding parts.
Cialis has helped millions of men to get a firm erection for a satisfactory sexual encounter. If you are suffering from erectile dysfunction, the doctor can suggest this medication. Read below to learn more about this pill.
Tadalafil is the active substance present in the erectile dysfunction treatment drugs and is mainly responsible for the curing effect. The best aspect of this drug is that it lets you enjoy the moment rather than choose the moment. It lets you go with the flow of the act and hence attain erection
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Tadalafil belongs to a family of medications known as PDE5 inhibitors. This active ingredient works in your body to prevent the action of phosphodiesterase Type 5 inhibitor. This is an enzyme that breaks down the cyclic guanosine monophosphate cGMP, a substance that is responsible for firmer and longer-lasting erections. The action of this Cialis ingredient increases the levels of cGMP, which relaxes the smooth muscles and also improves the blood flow to the spongy penile tissues known as the corpus cavernosum. An increase in blood flow ensures an erection that lasts long enough for satisfactory sexual intercourse.
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Filagra serves a sensational formula to deal with the troubles of Erectile Dysfunction. The medicine boosts up blood flow to the penile making it easier for the sexually aroused man to experience passionate sex. The powerful medicine improves erectile performance by promoting satisfactory sex life. Impotence in men makes it extremely difficult for the sexually aroused man to feel complete satisfaction and enjoy sex without any breakdowns. The sexual rut disrupts the erotic abilities reducing arterial complications and by improving overall sexual performance in men.
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I AM A KIDNEY TRANSPLANT PATIENT AND I TAKE A VARIETY OF DRUGS FOR SUPPRESSION OF MY IMMUNE SYSTEM. BUT WEIGHT GAIN NEVER INCREASED AT THIS RATE UNTIL PLACED ON THESE TWO DRUGS. NOW ON LASIX TO REMOVE THE FLUID WEIGHT GAIN. WEIGHT WENT FROM 255 TO 285 IN A SPAN OF 3 OR 4 MONTHS.
I have a drug patch on my arm and results came back positive for meth. This is impossible unless one of my medications caused this. Any input would be helpful.
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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With a slogan like Live Large, you can expect big results from Enzyte, a male enhancement product that is used by 5 million users.
The Enzyte website claims Enzyte is the 1 selling male enhancement supplement in the world.
Although were eager to believe that Enzyte will work as well as it is supposed to, we wanted to be sure. So we did research on the ingredients to see if they are safe and effective.
There are several key ingredients in the Enzyte formula. They are part of a proprietary blend, meaning that there is no information about how much of each ingredient is in the Enzyte formula. They are all fantastic ingredients, however, so we are going to take a closer look.
Ginkgo Biloba : Improves cardiovascular function so that blood can flow freely into your penis in preparation for sexual intercourse.
Horny Goat Weed Extract : Also increases cardiovascular function, lowers blood pressure, increases sperm and testosterone production which gives you a better quality erection.
Korean Ginseng : A tonic that improves overall health, including sexual stamina.
L-Arginine : An amino acid that increases blood flow, which supports sexual function.
Tribulus Terrestris Extract : Stimulates sexual behavior and increases testosterone levels.
If you use Enzyte, there is a risk of certain side effects. These include upset stomach, headache, dizziness, constipation, forceful heartbeat, allergic reactions, vomiting, dry mouth, thirst, nosebleed, insomnia, abdominal pain, bloating, diarrhea, gout, blood abnormalities, airway inflammation, worsening of asthma, and low blood pressure.
Even though the list is a bit long, these side-effects are all mild and rare. If you use Enzyte, the chance of experiencing side effects is low. If you do experience side effects, however, they will not be severe and they will only be temporary.
A 90-day supply of Enzyte costs 89 on the official website. After looking over the website, we notice that there is a 60-day money back guarantee. However, you have to look hard and read some find print before finding the guarantee.
After looking over Enzyte completely, it seems like a good male enhancement. It is affordable, has a money-back guarantee, and has great ingredients. Our one concern is the proprietary blend, which does not reveal how much of each ingredient is in Enzyte. Enzyte may work for some people but not for others.
Zytenz is the most effective male enhancement weve ever reviewed. Its proven ingredients are 100% GUARANTEED to deliver harder erections and more satisfying sex for you and your partner!
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In a study of healthy male volunteers 18 50 years, the mean C max and AUC of vardenafil from Staxyn were higher by 15% and 44%, respectively compared to 10 mg vardenafil film-coated tablets.
Vardenafil was not found to accumulate in plasma when Staxyn was dosed daily over ten days.
Effect of food: A high fat meal had no effect on vardenafil AUC and T max from Staxyn in healthy volunteers and reduced C max by 35%. Clinical trials for Staxyn were conducted without regard to meals. Staxyn can be taken with or without food.
Effect of water: When Staxyn was swallowed with water, the AUC of vardenafil was reduced by 29% and median T max was shortened by 60 minutes while C max was not affected. In clinical trials, dosing was done without water. Staxyn should be taken without liquid.
The mean steady-state volume of distribution Vss for vardenafil is 208 L, indicating extensive tissue distribution. Vardenafil and its major circulating metabolite, M1, are highly bound to plasma proteins about 95% for parent drug and M1. This protein binding is reversible and independent of total drug concentrations.
Following a single oral dose of 20 mg vardenafil film-coated tablet in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing.
Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 is subject to further metabolism. The plasma concentration of M1 is approximately 26% that of the parent compound. This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. Therefore, M1 accounts for approximately 7% of total pharmacologic activity.
The mean terminal half-life of vardenafil in patients receiving Staxyn tablets varied between about 4 6 hours. The elimination half-life of the metabolite M1 is between 3 to 5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the feces approximately 91 95% of administered oral dose and to a lesser extent in the urine approximately 2 6% of administered oral dose. Vardenafil is a high clearance drug with a plasma clearance of 56.4 L/h following intravenous administration.
Staxyn is not indicated for use in pediatric patients. Vardenafil trials were not conducted in the pediatric population.
Vardenafil AUC and C max in elderly patients 65 years or older taking Staxyn were increased by 39% and 21%, respectively, in comparison to patients aged 45 years and below see Use in Specific Populations 8.5.
In volunteers with mild hepatic impairment Child-Pugh A, the C max and AUC following a 10 mg vardenafil film-coated tablets dose were increased by 22% and 17%, respectively, compared to healthy control subjects. In volunteers with moderate hepatic impairment Child-Pugh B, the C max and AUC following a 10 mg vardenafil film-coated tablets dose were increased by 130% and 160%, respectively, compared to healthy control subjects. Vardenafil has not been evaluated in patients with severe Child-Pugh C hepatic impairment.
Physical adds-on, such as Bluetooth beacons Apple, Paypal, Estimotes provides the ultra-localized experience to interact with the products themselves, but should disappear when products become connected themselves
There has been a flurry of POS and wallet startups following Squares success. However not a lot of them have shown as much success. More established players, such as Paypal, getting in the market have not helped.
User acquisition is particularly difficult in B2B markets, especially for small and medium businesses though signing mainstream chains is another important challenge. This plays a role in the vertical acquisitions we have seen were acquirers/processors have moved to buy Point of Sales startups. Their customer acquisition weight is just too important and their margins are being compressed by rates reduction and competition.
On the other hands, the demands of data enriched services is pushing for more horizontal organizations where connectivity to payment, accounting, global CRM, ecommerce and devices are becoming key. This is where Amazon acquiring POS software could fit. Squares success as a stand alone company also depends on it.
In service businesses. They have been facing less competitions than merchants businesses from the online world and, after the Groupon experiment, are looking to build repeat business.
In the expension of Bluetooth LE. It couldbe the first local connectivity technology to reach the masses. Bluetooth LE success might not come from marketing but from recreating value with the customer in enhancing support.
In online businesses going offline. New stores opened by brands such as Bonobo, Warby Parker are interesting to follow. But more importantly Apple is leading the way here, the Apple Store App is probably the most undervalued example of the new Point of Sale paradigm.
As the POS is moving from accepting payments, to accepting wallets, to enhancing the customer relation, there is plenty of opportunities for startups to help reinvent retail in the digital world.
After an eventful last year, 2014 is starting with more debate and conversations around Bitcoin.
It is often said that understanding Bitcoin is too technical for the average user and at core it is, for a good summary of Bitcoin, this things the following is one of my favorite posts: /bitcoin/, but understanding Bitcoin advocates might be an easier tasks. In my view they split among 3 categories:
The Libertarian : he is most likely an early Bitcoin supporter. As mentioned by the ECB, his economic background comes from the Austrian school, they see in Bitcoin a competitive currency with the main advantage of not being linked to any State. Often a goldbug as well, he considers the limit of 21 million or so Bitcoins an important advantage as well. The deflationary nature of Bitcoin is an asset.
How to spot him: look for mentions of Hayek, fiat currency, algorithmic currency
The Speculator : he bought Bitcoin at X and now it is at Y. Will share any rumours mentioning a high Bitcoin price. Bitcoin the new currency in China: share. Bitcoin coming from Alpha Centauri thanks azeem : share. He is a Libertarian when needed and a Protocolist as well.
Your personal health care specialist can then inform you if its safe to use Cialis for women, and if so, the appropriate dosage. All Cialis for women pills sold on this site are fivemilligrams as well as twentymilligrams. Smaller dosages of Cialis for women can be achieved by splitting the tablets. For instance, if you have had liver or kidney problems or youre over the age of sixty-five, the appropriate dosage of Female Cialis may be fivemilligrams. As well if you are using alpha blockers no more than fivemilligrams of this medical product should be taken during four hours of your alpha blocker dosage. Under no circumstances you shouldnt Cialis for women take more than once a day.
Follow the instructions for using this medical product provided by your personal health care specialist. Take Cialis for women tablets exactly as directed.
Hence, Cialis for women is reliable, efficient, easy to use and also secure; this medicinal agent restores the normal sexual life for women who suffer from sexual dysfunction, and freeing them from the continuous thoughts about treatment. It is a new medication for tackling problems such as female sexual dysfunction and female sexual desire disorder, which is created by scientists to meet the sexual needs as well as extend pleasure. It improves testosterones in the blood the women, increases libido in, enhanced sensitivity to stimulation. Female Cialis
Hmmm, well they are doing trials for women so they must be affected in some way. Perhaps increased blood flow. Cialis and Viagra help a man increase the blood flow into the penis and help him retain that blood. When stimulated a man produces a chemical that opens the channels into the penis wide to bring in blood. When the chambers are full they press on the veins that lead out with closes them like bending a hose so the blood cannot flow out. This chemical is broken down by the body after a short while, in men with ED erectile dyfunction it is broken down too fast. Drugs like Cialis prevent the breakdown of this chemical. Women do not produce this chemical. They do have spongy tissues that fill with blood when aroused but the blood flows in and out constantly, it isnt trapped like in a man. Cialis does not make you hornier or cause the erection on its own. It simply helps you keep the one you have longer. If you dont have ED taking drugs like Cialis can be very dangerous. It will prevent that chemical from breaking down meaning that even after you come you wont be able to get rid of the erection in extreme cases, more than four hours, this can lead to tissue death, it is also very painful. Women taking Cialis might have increased blood flow after they are aroused leading to greater sensitivity, but it wont make them hornier or help them get aroused. Women mostly have a naturally lower libido BUT they get aroused just as easily as men in a purly physical way. Most women with low libidos dont have a blood flow problem. Stimulation or even seeing pornography will cause increased blood flow to the vagina and surrounding tissue BUT she doesnt feel any increased desire. For most men arousal physical can create desire mental and vice versa. For most women they are seperate. Desire usually creates arousal but not the other way around. So, if a lady is feeling strong desire but doesnt get a lot of sensation, even with proper stimulation for at least 15 min. then maybe a drug that improves blood flow will help her.
The efficacy of the coadministration of an alpha-blocker and CIALIS for the treatment of BPH has not been adequately studied, and due to the potential vasodilatory effects of combined use resulting in blood pressure lowering, the combination of CIALIS and alpha-blockers is not recommended for the treatment of BPH. see Dosage and Administration 2.7, Drug Interactions 7.1, and Clinical Pharmacology 12.2.
Patients on alpha-blocker therapy for BPH should discontinue their alpha-blocker at least one day prior to starting CIALIS for once daily use for the treatment of BPH.
CIALIS should be limited to 5 mg not more than once in every 72 hours in patients with creatinine clearance less than 30 mL/min or end-stage renal disease on hemodialysis. The starting dose of CIALIS in patients with creatinine clearance 30 50 mL/min should be 5 mg not more than once per day, and the maximum dose should be limited to 10 mg not more than once in every 48 hours. see Use in Specific Populations 8.7.
Due to increased tadalafil exposure AUC, limited clinical experience, and the lack of ability to influence clearance by dialysis, CIALIS for once daily use is not recommended in patients with creatinine clearance less than 30 mL/min see Use in Specific Populations 8.7.
Due to increased tadalafil exposure AUC, limited clinical experience, and the lack of ability to influence clearance by dialysis, CIALIS for once daily use is not recommended in patients with creatinine clearance less than 30 mL/min. In patients with creatinine clearance 30 50 mL/min, start dosing at 2.5 mg once daily, and increase the dose to 5 mg once daily based upon individual response see Dosage and Administration 2.6, Use in Specific Populations 8.7, and Clinical Pharmacology 12.3.
In patients with mild or moderate hepatic impairment, the dose of CIALIS should not exceed 10 mg. Because of insufficient information in patients with severe hepatic impairment, use of CIALIS in this group is not recommended see Use in Specific Populations 8.6.
CIALIS for once daily use has not been extensively evaluated in patients with mild or moderate hepatic impairment. Therefore, caution is advised if CIALIS for once daily use is prescribed to these patients. Because of insufficient information in patients with severe hepatic impairment, use of CIALIS in this group is not recommended see Use in Specific Populations 8.6.
Patients should be made aware that both alcohol and CIALIS, a PDE5 inhibitor, act as mild vasodilators. When mild vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased. Therefore, physicians should inform patients that substantial consumption of alcohol, 5 units or greater in combination with CIALIS can increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache see Clinical Pharmacology 12.2.
CIALIS is metabolized predominantly by CYP3A4 in the liver. The dose of CIALIS for use as needed should be limited to 10 mg no more than once every 72 hours in patients taking potent inhibitors of CYP3A4 such as ritonavir, ketoconazole, and itraconazole see Drug Interactions 7.2. In patients taking potent inhibitors of CYP3A4 and CIALIS for once daily use, the maximum recommended dose is 2.5 mg see Dosage and Administration 2.7.
Vision problems: If you experience a sudden loss of vision in one or both eyes or other vision-related problems, contact your doctor immediately. Vision loss may be partial or complete. While in some cases the condition may improve over time, it can be permanent in other cases. This rare condition is more likely to occur if you have heart disease, high blood pressure, high cholesterol, diabetes, or eye problems, if you are more than 50 years old, or if you smoke.
Pregnancy and breast-feeding: Tadalafil is not intended for use by women.
Children and adolescents: Tadalafil is not intended for use by children or adolescents under 18 years old.
alpha-blockers, doxazosin, terazosin
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nitrates, nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, or amyl nitrite poppers
other medications for erectile dysfunction, sildenafil, vardenafil
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If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
stop taking one of the medications,
change one of the medications to another,
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An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter non-prescription, and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical conditions and treatments. This site is not a substitute for medical advice.
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Tadalafil has been assigned to pregnancy category B by the FDA. Animal data have failed to reveal evidence of teratogenicity or fetotoxicity. There are controlled data in human pregnancy. Tadalafil is only recommended for use during pregnancy when benefit outweighs risk.
There are no data on the excretion of tadalafil in human milk. The manufacturer recommends that caution be used when administering tadalafil to nursing women.
In rare instances, men taking prescription ED tablets, including CIALIS, reported a sudden decrease or loss of vision or hearing sometimes with ringing in the ears and dizziness. Its not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision or hearing, stop taking any ED tablet, including CIALIS and call a healthcare provider right away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit /medwatch or call 1-800-FDA-1088.
protect a man or his partner from sexually transmitted diseases, including HIV
CIALIS is available by prescription only. For additional information, talk to your healthcare provider and see full Patient and Prescribing Information.
The brand listed is a trademark of its respective owner and is not a trademark of Eli Lilly and Company. The maker of this brand is not affiliated with and does not endorse Eli Lilly and Company or its products.
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The warrior code takes a soldier and makes him a knight. It connects the natural life of a fighter to the supernatural understanding of the warrior calling. His duties are transformed into holy sacrifices; his sense of self is reformed into the image of the servant in pursuit of valor. He becomes part of a fellowship, a noble tradition that flows thru him and carries him beyond the mediocre and the vain. Steven Mansfield, The Faith of the American Soldier
I have worn a warrior suit, of one form or another, most of my adult life first as a navy pilot, then state guardsman and law enforcement official. Now at age 66 I can say, without reservation, that Steven Mansfield has uncovered a great truth. In fact, the truth of his statement transcends historical and cultural divides.
A warrior code is necessary in our fallen world because of the presence of evil and the chaos and violence it produces. We become aware of this violence early on in the Genesis text. In chapter 4, we learn the details of a homicide in which Cain, in an outburst of anger, murders his brother Abel. This violence continues today often serving as the lead story on local, national, and international news reports from around the world. more
In selecting men for office, let principle be your guide. Regard not the particular sect or denomination of the candidate look to his character.
Noah Webster, Letters to a Young Gentleman Commencing His Education, 1789
Well, the race for Congress didn t turn out the way I had hoped I came in 8th out of 16 in the primary!. But at least it got me back home and available for a new opportunity. So, now that I m back in the states, at least on the short-term, I ve got two things going on. First, I am available for live Police Dynamics conferences. If you re interested, please send me a message via the Contact Me button on the left of your screen.
But an even more important announcement is that the Police Dynamics Institute has partnered with the International Academy of Public Safety IAPS and brought me on-board as the VP of Law Enforcement Training and Development. IAPS, and its sister company Readiness Network, are fully integrated Technology and e-Learning companies. Their iLEARN, iCOMMAND, and iSHIELD portals create an ecosystem that acts as the connective tissue for command and control with comprehensive learning and development tools that enhances readiness at all levels. Dr. Mitch Javidi, founder and CEO of IAPS, contacted me about a year ago while I was still overseas about incorporating some of the Police Dynamics training videos into iSHIELD SHeriff s Institute for Ethical Leadership Development. Since then, we have planned to partner together whenever I got back home.
Here s the introductory video from our series on Reflective Leadership which will be available soon. And we plan to have the entire Police Dynamics program online in the near future.
There is much more to talk about in regards to IAPS and iSHIELD but I will leave it at that for now. Please contact me if you would like to learn more or to schedule a demonstration of the system.
Of the total number of subjects in clinical studies of tadalafil, approximately 25 percent were 65 and over, while approximately 3 percent were 75 and over. No overall differences in efficacy or safety were observed between subjects over 65 years of age compared to younger subjects, therefore no dose adjustment is warranted based on age alone. However, a greater sensitivity to medications in some older individuals should be considered. See Clinical Pharmacology 12.3.
In clinical pharmacology studies, tadalafil exposure AUC in subjects with mild or moderate hepatic impairment Child-Pugh Class A or B was comparable to exposure in healthy subjects when a dose of 10 mg was administered. There are no available data for doses higher than 10 mg of tadalafil in patients with hepatic impairment. Insufficient data are available for subjects with severe hepatic impairment Child-Pugh Class C. See Dosage and Administration 2.3 and Warnings and Precautions 5.8.
In clinical pharmacology studies using single-dose tadalafil 5 to 10 mg, tadalafil exposure AUC doubled in subjects with mild creatinine clearance 51 to 80 mL/min or moderate creatinine clearance 31 to 50 mL/min renal insufficiency. In subjects with end-stage renal disease on hemodialysis, there was a two-fold increase in C max and 2.7- to 4.1-fold increase in AUC following single-dose administration of 10 or 20 mg tadalafil. Exposure to total methylcatechol unconjugated plus glucuronide was 2- to 4-fold higher in subjects with renal impairment, compared to those with normal renal function. Hemodialysis performed between 24 and 30 hours post-dose contributed negligibly to tadalafil or metabolite elimination. In a clinical pharmacology study N28 at a dose of 10 mg, back pain was reported as a limiting adverse event in male patients with moderate renal impairment. At a dose of 5 mg, the incidence and severity of back pain was not significantly different than in the general population. In patients on hemodialysis taking 10- or 20-mg tadalafil, there were no reported cases of back pain. See Dosage and Administration 2.3 and Warnings and Precautions 5.7.
Single doses up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. Hemodialysis contributes negligibly to tadalafil elimination.
CIALIS tadalafil, an oral treatment for erectile dysfunction, is a selective inhibitor of cyclic guanosine monophosphate cGMP-specific phosphodiesterase type 5 PDE5. Tadalafil has the empirical formula C 22 H 19 N 3 O 4 representing a molecular weight of 389.41. The structural formula is:
The chemical designation is pyrazino1,2 :1, 6pyrido3, 4-bindole-1, 4-dione, 6-1, 3-benzodioxol-5-yl-2, 3, 6, 7, 12, 12a-hexahydro-2-methyl-, 6R, 12aR-. It is a crystalline solid that is practically insoluble in water and very slightly soluble in ethanol.
CIALIS is available as film-coated, almond-shaped tablets for oral administration. Each tablet contains 2.5, 5, 10, or 20 mg of tadalafil and the following inactive ingredients: croscarmellose sodium, hydroxypropyl cellulose, hypromellose, iron oxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, talc, titanium dioxide, and triacetin.
You can also inquire about one of the low-cost alternatives and herbal remedies that are available. No longer are men slaves to the Pfizer corporation and their little blue pill. We can go out and get the same result from products costing far less, but that are just as effective.
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Of course Viagra works. The worst thing that can be said about it is that works too well. Some men find that taking a half, or even quarter of a pill or less does the trick just fine. A whole pill will have you raring to go, so just hope that the missus is in the mood as well. Of course, the other major worry with Viagra is those darn erections lasting more than four hours. Those can cause permanent damage, so seriously, head directly for the hospital after three and a half hours. Thats a medical emergency you want to attend to ASAP.
This stuff works so well that it is being used by a lot of young people, people who don t need to use it, as a recreational drug. Not because it alters your mood or has any kind of serotonin boosting properties, but because the erection experienced by those who have an otherwise normal erection, are dramatic. Not only does it make the penis harder for longer, but the effect is like having a bigger, stronger penis. It s like when you get really aroused and your erection seems like it will burst. That feeling never lasts very long. It will last for hours like that on Viagra. Not that I m condoning the recreational use of the drug, I m just saying. Obviously.
Real Reviews. Real Answers.
If youre on the face of the Earth youve definitely seen a Viagra ad and wondered whether it would work for you. The short answer is yes, but theres far more to the answer than that. Its important to know where Viagra came from, why it got so popular, and why it works the way it does.
The entire world of male sexual enhancement was rocked when Viagra came out. It totally was groundbreaking medicine and both men and women alike took notice. Quickly making a name for itself in the global mainstream consciousness, Viagra has had many imitators and competitors come out over the years. Since its patent has expired you can also find many generic versions with the same dose, at far cheaper prices.
Its scientific name is Sildenafil and it was brought to market first by Pfizer, which took the lions share of profits from its revenues. No doubt they are looking to market products that are even better than Viagra, but until then they are trying to milk their cash cow for all its worth.
The claim is that its a fix for erectile dysfunction in men, allowing for a return to normal sexual activity. Aside from a cure for hair loss, this is the biggest pharmaceutical news to ever come out at the time.
Tons of commercials, junk email offers, racing cars, and overall consumer-to-consumer hype has made Viagra quite a phenomenon. Almost everyone knows about Viagra, and it enjoys this status because it was the first to market, and the only guaranteed effective remedy to sexual problems for several years.
One drawback that Viagra has is the price. Since its not covered by most insurances, most men had to pay out of pocket for the pills, each costing upwards of 80 when it first came out. All that has changed now and you can get it or one of its duplicate generic brands for far less.
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Nexus Pheromones is pure science. This powerful product omits a certain scent that makes women more attracted and drawn to the man wearing them. If you have not tried a pheromones product before, its definitely time to step up your game. This product has been proven to work for all users in some way or another. Nexus Pheromones can even be worn alongside your favorite cologne without dampening the effects! Some men use this to help them be more successful in meeting women, and others use it just in casual social occasions. Beyond enticing the opposite sex, Nexus Pheromones is proven to help boost confidence because of the heightened level of positive interaction one receives. This is a quality form of pheromones, and their customers like them. Read a Full review of Pheromones here.
It is likely that many consumers are already familiar with GenF20 Plus as it is becoming the top HGH releaser now available on the market. HGH levels can boost vigor, improve health and even enhance ones appearance, and GenF20 Plus is fully equipped to ensure that a users HGH levels are restored to maximum levels. GenF20 Plus is so effective as it uses a dual-product system that will ensure results are optimized and fast-acting. The end results are gains in HGH levels, which in turn can impede the hand of time so that users may feel that they are in their 20s and 30s again. The blog posts are very positive on this product. Learn More, Read the Full review of GenF20 Plus here.
Flex Arms is a product designed by a company who makes a variety of effective muscle toning machines. This one also uses the proven EMS technology, to strengthen and train the muscles of the arms. The electronic technology is medical grade and FDA cleared, lending the Flex Arms some serious results. People who have used this product have seen results in just weeks. They simply put the Flex Arms on, turn it on, allowing it to strengthen their arms while they relax. This device is a way for people to tone their muscles when they want to. Best of all you can wear Flex Arms as you go about your daily business. The Blogs and reviews are nearly all positive for the Flex Arms. Check out what people have to say. Learn More, Read the Full review of Flex Arms here.
If you are ready to make some serious gains look no further than HyperGH 14x. HyperGH 14x is likely the most advanced supplement system on the market for men who aim to increase muscle mass, strength and endurance. This product takes advantage of the bodys natural HGH production system by packing the natural formula with potent HGH precursors. This means that supplementation can stimulate HGH release in the body. The company even found that when men train, they can stimulate the release of even higher HGH levels. This means the more your work, the more muscle strength you gain. The best part of this formula is that no prescription is required. Learn More, Read the Full review of HyperGH 14x here.
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July 6, 2010 - - Men prescribed drugs for erectile dysfunction are two to three times more likely to contract sexually transmitted diseases STDs, particularly HIV or chlamydia, than men who are not prescribed ED treatments, researchers
CIALIS tadalafil is a selective inhibitor of cyclic guanosine monophosphate cGMP-specific phosphodiesterase type 5 PDE5. Tadalafil has the empirical formula C22H19N3O4 representing a molecular weight of 389.41. The structural formula is:
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Zenerx is a male enhancement supplement targeting middle-aged men and is marketed as an alternative to regularly prescribed sexual dysfunction products, which only help you achieve an erection; Zenerx, like all top selling maleenhancementsupplements, also claims to deliver greater stamina, increased libido and pleasure, and increased sexual energy.
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Run by the Olkiramatian Womens Group Community, Laleenok pioneers new approaches to research, conservation and rangeland development. Rooted in the traditional coexistence between Maasai and wildlife, the conservancies have seen elephants return to the South Rift, wildlife herds double, lion numbers triple and cheetahs and wild dogs become regular visitors. The conservancies also double as traditional grass banks that cut livestock losses in drought, promote rotational grazing and ease competition between wildlife and livestock.
Laleenok recently launched Rebuilding the Pride, a program that draws on traditional practices to promote coexistence between wildlife and people to mutual advantage. Rebuilding the Pride aims to show that coexistence is not only possible, but is the best hope of sustaining large viable wildlife populations beyond and between parks to the benefit of local commumnities.
This program was conceptualized out of a need to empower communities to better understand their environment through monitoring of the rangeland. Read more
ACC has produced an elephant suitability map of the South Rift, plotting out areas most suitable for elephants, the wet and dry season movement pathways, potential sanctuary areas and no-go areas. Read more
ACC has concentrated its efforts working with pastoral communities helping them further understand and care for their resources. Read more
Following a three-day International Conference on Biodiversity, Land-use and Climate Change held on September 15-17, 2010 in Nairobi, a special policy session of the more
ACC s encompassing view of science means that all forms of knowledge either from natural sciences. Read More
Livestock is a key asset in the arid and semi-arid areas of the South Rift region. The livelihoods of pastoralists Read More
was set up to provide our friends in the USA with a passion for Africa, her wildlife and people - a bridge between ACCs conservation efforts Click
Copyright 2014. African Conservation Centre.
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Drug Class: Pro-Sexual Cialis Tadalifil citrate is essentially a much longer lasting version of the erectile dysfunction drug Viagra more or less. Most people are familiar with Viagra, and know that it provides increased blood flow to external genitalia the penis for approximately 6-8 hours, thereby helping to temporarily relieve erectile dysfunction. The major difference here is that Viagra can give you an erection for 6-8 hours, while Cialis is good for 36-48 hours. This makes it a much better buy, in terms of economics, as you are getting a window of opportunity that lasts substantially longer with Cialis. In fact, currently out of the three popular erectile dysfunction medications Cialis, Viagra, and Levitra - Cialis is easily the one which lasts the longest. Since my audience is primarily steroid using men, I m going to guess that most of them aren t having a problem in the erections department unless it s because they re having too many of them!
So what I really think Cialis is good for is men who against my recommendations have chosen to run Deca only cycles or Tren only cycles, and found that erectile dysfunction followed. Also, during PCT, Cialis is a good occasional choice, when you re waiting for your natural hormonal levels to return.
Although PCT is only typically 6 weeks long, Cialis has been shown to be safe in treating erectile dysfunction for up to 6-months 1. In one study, improved erectile function and sexual intercourse success rate for those using Cialis was 73.5% 1.
This may provide additional benefits during PCT, because lack of sexual activity due to erectile dysfunction can decrease testosterone levels through anl effect on the hypothalamic-pituitary axis HPTA 2. As you can expect, when you are having successful sex, your testosterone levels actually go up, and when Cialis was given to men for a month, and at the end, they had considerably higher testosterone levels when compared with their previous levels, probably because of this additional sex2.
One study indicates that you can use it for up to 3x a week 1. Since it lasts 36 hours each time, this means you are covered for the entire week, more or less. In addition, Cialis was well tolerated, had very few sides, and was very effective at increasing the success rate of sexual intercourse attempts 13.
I think that even if you ve never has erectile dysfunction, Cialis is a good thing to have on hand during PCT. But hey, only if you enjoy getting laid.
1. A 6-month study of the efficacy and safety of tadalafil in the treatment of erectile dysfunction: a randomised, double-blind, parallel-group, placebo-controlled study in Australian men. Int J Clin Pract. 2005 Feb;592:143-9.
2. Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels. Clin Endocrinol Oxf. 2004 Sep;613:382-6.
3. Efficacy and treatment satisfaction with on-demand tadalafil Cialis in men with erectile dysfunction. Eur Urol. 2004 Sep;463:362-9; discussion 369.
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The company has conceded that it has no scientific studies that substantiate any of its Enzyte claims.
Dr. Ira Sharlip, a spokesman for the American Urological Association, has said, There is no such thing as a penis pill that works. These are all things that are sold for profit. Theres no science or substance behind them.
Despite being a mixture of herbs, minerals, and vitamins, Enzyte formerly promoted itself under the seemingly scientific name of Suffragium asotas. While Enzytes manufacturer claims this term translates as better sex, this is incorrect: Suffragium in Latin means vote, and asotas is not a Latin word at all. Harvard teaching fellow Rhett Martin says that the term might be an erroneous form of suffragor asotis, meaning refuge for the dissipated.
Most of the above ingredients are commonly available as over the counter herbal or dietary supplements, and most have anecdotal reports, but marginal or unproven scientific evidence, of efficacy on various systems in the human body. Several of the herbal ingredients are included only in very low quantities.
One notable ingredient, yohimbe, was included in the original formulation of Enzyte, produced until at least 2004; however, as yohimbe s legal status in Canada is unclear, Enzyte produced after 2004 no longer contains yohimbe extract.
Additionally, zinc is an ingredient in Enzyte. Some men who have low zinc levels in their body have had success using zinc supplements to treat erection problems.
Overdosage of zinc is a hazard to health. Zinc supplements are available without prescription at significantly lower prices than Enzyte.
Currently, the effectiveness of Enzyte is unproven. The Center for Science in the Public Interest has urged the Federal Trade Commission which has power under federal law to regulate advertising to disallow further television advertising for Enzyte because of a lack of proper clinical trials. The company has agreed to pay 2.5 million to settle allegations of deceptive sales practices made by the attorneys general of various states
and has altered its advertising to be more truthful.
Enzyte originally advertised that use of the Enzyte product would promote permanent physical penile growth or the company would return purchasers double their cost. Those who attempted to collect this refund claim they either received a partial refund or were duped into signing away the right to a refund. Enzyte advertising was changed to state that the product is intended to create a firmer erection by temporarily increasing blood flow to the penis. The advertising change was made after lawsuits against the company and its rebate policies began to surface. No evidence exists showing Enzyte to be effective in any of its claims. The product advertising states in small print that it is not intended or promoted to diagnose, or treat any disease and since erectile dysfunction is a recognized disease, the advertising is considered legal.
A civil lawsuit alleged Enzyte does not work as advertised.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Levitra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Levitra as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Levitra. Talk to your pharmacist if you have questions about this information.
Take Levitra by mouth with or without food.
Take Levitra about 1 hour before sexual activity.
Do not take Levitra more often than once daily, or as directed by your doctor.
Check with your doctor before you eat grapefruit or drink grapefruit juice while you use Levitra.
If you miss a dose of Levitra and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor.
Ask your health care provider any questions you may have about how to use Levitra.
Levitra may cause dizziness, drowsiness, fainting, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Levitra with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Levitra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
Patients with heart problems who take Levitra may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion; vision or speech changes; one-sided weakness; or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms.
Levitra may rarely cause a prolonged more than 4 hours or painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
Levitra does not stop the spread of HIV or other sexually transmitted diseases STDs to others through sexual contact. Use barrier methods of birth control eg, condoms if you have HIV infection or an STD.
Levitra will not prevent pregnancy. If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control.
Levitra may uncommonly cause mild, temporary vision changes eg, blurred vision, sensitivity to light, blue/green color tint to vision. Contact your doctor if vision changes persist or are severe.
Rarely, an eye problem called nonarteritic anterior ischemic optic neuropathy NAION has been reported in patients who took Levitra. This may lead to decreased vision or permanent loss of vision in some cases. If you notice a sudden decrease in vision or loss of vision in one or both eyes, contact your doctor right away.
Sudden decreases in hearing and loss of hearing have been reported in some patients who have taken Levitra. Sometimes they also noticed ringing in the ears or dizziness. If you notice a sudden decrease or loss of hearing, contact your doctor right away.
After seeing all the television commercials, you probably want to read these Enzyte reports. These Enzyte reviews should answer any questions you may have regarding the truth about Enzyte effectiveness. The truth is, these Enzyte reports were written after a detailed examination of the product, the manufacturer, and the results from people who tried it. Please read some of the other Enzyte information available on the Internet so you can learn the truth about Enzyte effectiveness. You will see why we recommend Enzyte over many other products.
Enzyte is one of the most well known names in the male enhancement industry. Smiling Bob, Enzytes marketing icon, is practically a household name. In truth, product testers put Enzyte in the top five most effective penis enlargement pill products on the market today. Berkeley Nutraceuticals, the manufacturer of Enzyte, has been in the herbal supplement business for over ten years. Steve Warshak, the chief executive of Enzytes manufacturer, has been in the news recently. Many believe it is because he sells a bogus product. This is not the truth. The truth is Warshak was indicted on 112 federal counts, including conspiracy; money laundering; and mail, wire, and bank fraud. Although his greed and criminal nature may land him in jail for up to 20 years, the truth is his product, Enzyte, showed an amazingly level of effectiveness.
Product testers from these Enzyte reports experienced extreme levels of success. In the first couple weeks of usage, Enzyte testers experienced immediate increases in the firmness of their erections. The truth is, by the end of the first month of Enzyte use, over 70% reported they had seen a noticable increase in both the length and girth of their erections. 60% of the Enzyte users reported experiencing at least two inches of additional length, and over 75% said they noticed an increase in staying power and a faster recovery time after using Enzyte. In truth, you just cant ask for greater levels of effectiveness.
The vast majority of product testers experienced outstanding results with Enzyte. Over 80% of the Enzyte product testers said they experienced a noticeable increase in length and girth, with over 20% claiming huge increases. 40% of our Enzyte users reported better ejaculation control and increased sexual stamina after using Enzyte. Unlike other products, our product testers experienced extremely fast results a one-inch increase in length within the first month of use with Enzyte. Enzyte users, on average, said they gained as much as 2.5 inches in length and a 30% increase in girth. With a success rate of over 90%, you can be confident that you will get excellent results with Enzyte.
Enzyte is made from a proprietary blend of herbal complexes proven for their effectiveness. These Enzyte ingredients have a proven track record for increasing blood flow to the penis. These Enzyte ingredients include Saw Palmetto, Korean Red Ginseng, Ginko Biloba, Horny Goat Weed, Avena Sativa, Tribulus Terrestris, Muira Puama, L-Arginine, Maca Root, Saw Palmetto Berry, and Swedish Flower Pollen.
Lastly, we really liked that the manufacturer of Enzyte offers a 60-day money-back guarantee. This demonstrates their confidence that you will see results with Enzyte. If you would like more info, you can get it directly from the website. Learn the truth about Enzyte effectiveness, absolutely risk free.
Berkeley was incorporated in Cincinnati, Ohio in 1996 to offer vitamin and food supplements. The Cincinnati Better Business Bureau provides six websites associated with their products and twelve dietary supplements offered in their product line that fall under the 30 day offer advertised in the infamous commercials. Berkeley is not a member of the BBB and has not responded to the agencys request in July 2007 for more information about their home delivery plan and automatic billing policies which have been the subject of numerous complaints.
In 2006, Steven Warshak, the owner of Berkeley Nutraceuticals, was indicted on 112 federal counts including conspiracy, money laundering, and mail, wire, and bank fraud. Warshaks mother and five others were also named in the indictment along another of his companies, TCI Media Inc. The charges account for 100 million of a reported 250 million made by the company. Earlier that year, in March 2006, the Ohio class action suit had been settled for several million dollars; some sources state 4.7 million and others 2.5 million.
On February 22, 2008 a federal court handed down a guilty verdict for Warshak and his mother, as first reported by The Cincinnati Enquirer. The Berkeley owner and president could face 20 years in prison. Former employees had pled guilty and cooperated with prosecutors. The Associated Press reported that their testimony included claims of fictitious doctors, a fabricated customer-satisfaction survey, and made up numbers in Enzyte s claims.
As of 36 hours after the federal courts decision, the products website is still up and offering the supplements. The claims include the ability to produce firmer male arousal and increased sexual performance through increased blood flow. The ingredients include basic herbal and vitamin remedies such as zinc and niacin. The proprietary blend is the bulk of the pills and include gingko biloba and ginseng extracts as well as something curiously called horny goat weed. Also known as epimedium or yin yang huo, the plant is from old Chinese medicine and consists of many species of the leafy plant. Touted for the ability to increase libido, what is known is that the plant contains flavonoids, sterols, complex sugars polysaccharides, and magnaflorine. Flavonoids are antioxidants found in fruits and vegetables. What benefits the pills may deliver can actually be achieved by a good diet.
is not affiliated with any of the products reviewed on this site. These reviews are for informational purposes only. We recommend you consult with a doctor before using any penis enlargement treatments.
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Non-arteritic anterior ischemic optic neuropathy NAION, a cause of decreased vision including permanent loss of vision, has been reported rarely postmarketing in temporal association with the use of phosphodiesterase type 5 PDE5 inhibitors, including tadalafil.
Other side effects have included cases of sudden decrease or loss of hearing reported postmarketing in temporal association with the use of PDE5 inhibitors, including tadalafil the active ingredient contained in Adcirca In some cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In many cases, medical follow-up information was limited. It is not possible to determine whether these reported events are related directly to the use of tadalafil, to the patients underlying risk factors for hearing loss, a combination of these factors, or to other factors.
Hypersensitivity side effects have included Stevens-Johnson syndrome and exfoliative dermatitis.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
Opsumit macitentan has been approved by the Food and Drug Administration to treat adults with pulmonary arterial hypertension, a debilitating
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Note: This document contains side effect information about tadalafil. Some of the dosage forms listed on this page may not apply to the brand name Adcirca.
Some side effects of Adcirca may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Spark, RF. Overview of Male Sexual Dysfunction. In: UpToDate, Basow, DS Ed, UpToDate, Waltham, MA, 2010.
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
Copyright 2006-2014 Clinaero, Inc.
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When a man is sexually aroused, the body releases certain chemicals that relax the muscles in the penis. Normally, these muscles are constricted so that blood cannot flow into the penis. When the muscles relax, large amounts of blood are able to enter the penis, causing an erection.
An erection is reversed when an enzyme called phosphodiesterase type-5 PDE5 breaks down the chemicals that caused the penis muscles to relax in the first place. As the penis constricts again, the blood leaves the penis and the erection goes away.
Staxyn works by blocking PDE5. When PDE5 is blocked, the chemical that caused the penis muscles to relax cannot be broken down. Therefore, these muscles stay relaxed, blood stays in the penis longer, and the penis stays erect.
No - - Staxyn will not work without sexual stimulation. This is because the chemicals that cause an erection are released only when a person is aroused. Staxyn has no effect on these chemicals being released. It only keeps the chemicals in the penis longer.
The amount of time it takes for Staxyn to work can vary. For most men, it will likely begin to work in under an hour. Therefore, it is generally recommended that you take Staxyn an hour 60 minutes before sexual activity.
Staxyn is not approved for use in people younger than 18 years of age. It has not been studied in this age group, and should not be used in children.
This research is being done to compare the effect of tadalafil with placebo an inactive substance that looks like the study drug, but which should have no effecton the frequency of recurrent priapism prolonged erection, unassociated with sexual interest or desire and the nature of sexual experiences in male patients with sickle cell disease. The study will also look at the effect of tadalafil on pulmonary hypertension increased blood pressure in the blood vessels supplying the lungs.
Masking: Double Blind Subject, Investigator
The primary measure will be the determination of priapism frequency. This will be accomplished using routinely administered questionnaires. Time Frame: priapism questionnaire administered at baseline and monthly Designated as safety issue: No
Secondary measures will be the evaluations of the nature of sexual experiences and quality of life impact of priapism treatment. Time Frame: questionnaires administered monthly Designated as safety issue: No
This study will investigate PDE5 inhibitor therapy as a potential treatment using tadalafil for recurrent ischemic priapism. Patients meeting enrollment will be randomized to receive medication or placebo. Tadalafil 10mg or matching placebo oral tablets will be taken 3 times per week. Patients will be instructed to use the medication in the morning a few hours after awakening from night time sleep, and they will be instructed against engaging in any form of sexual activity or excitement within 8 hours of dosing. Treatment duration for each patient will be 2 months, which should sufficiently reveal whether priapism episodes have lessened. If improvement occurs in a patient who is identified to be on therapy after 2 months, continued open label treatment will be provided for an additional 2 months. In a patient who is identified not to be on therapy after 2 months, he will be offered therapy as open label treatment for 2 months. The study duration for each patient will not exceed 4 months.
Tests and procedures will include a screening/baseline visit for: consent; medical history; physical examination; clinical laboratory tests; completion of questionnaires; echocardiography and distribution of medication. Bi-weekly telephone calls between monthly office visits will include; clinical assessment, concomitant medication assessment; adverse event assessment; compliance with randomized study medication assessment and resupply of medication as needed.
All men 18 years of age and older with actively recurrent ischemic priapism, defined as multiple, self-limited erectile events characteristically less than 3 hours in duration occurring repeatedly at least twice a week in the absence of sexual interest or desire may be considered for enrollment
History of heart problems such as angina, heart failure, irregular heartbeats or myocardial infarction
History of diabetes, liver problems, or kidney problems
A glomerular filtration rate of 50ml/min.
History of retinitis pigmentosa or severe vision loss, including a condition called NAION
History of HIV, multiple myeloma, or leukemia
Johns Hopkins Outpatient Center; Johns Hopkins Medical Institutions
Baltimore, Maryland, United States, 21287
Arthur L. Burnett, , Johns Hopkins University
prolonged, painful erection
Anemia, Hemolytic, Congenital
Genetic Diseases, Inborn
processed this record on February 05, 2014
This study has been terminated.
First received: October 1, 2007
Last updated: July 26, 2010
Chinese football has become a showcase of what happens when match fixing is allowed to continue for too long. Fans and sponsors have almost given up on the sport, and in a new attempt to turn the tide, the China Foolball Association CFA and the Chinese police set up a task force in October 2006 to stamp out football corruption.
Match fixing is an old practice that has become easier because it is possible gamble on losers. The fixing of matches has become easier and is rapidly becoming a serious threat to the sport.
First, FIFAs early warning system is practically useless. They dont investigate. They dont protect the players. If you are a whistle-blower and you come forward to expose your fears, dont expect protection and dont expect the situation to improve.
To step up the fight against match-fixing before the 2010 World Cup, FIFA has set up a confidential hotline for players, coaches and referees to use if someone attempts to bribe them.
FIFA has been forced to call in international crime-fighters Interpol to form a task-force to combat a wave of match-fixing and bribery that is sweeping through the game.
Recognition or denial? Two very different approaches on how to tackle the threat of match fixing in football met journalist and author Declan Hill promoting his book The Fix in Belgium and the Netherlands.
Tennis was applauded by IOC President Rogge for its anti-match-fixing effort.
Sepp Blatter suggests that professional referees could put an end to match fixing. In England, the FA has a group of paid referees and so far no instances of match fixing. But in light of recent match fixing scandals, a refereeing career is short and may not pay enough to prevent future scandals.
Play the Game is an international conference and communication initiative aiming to strengthen the ethical foundation of sport and promote democracy, transparency and freedom of expression in sport. It is run by the Danish Institute for Sports Studies Idan, an independent institution set up by the Danish Ministry of Culture. Our offices are located at the Department of Sport Science, University of Aarhus, Denmark. Unless otherwise specified, all content on this website remains the copyright of Play the Game. However, reposting of information found on this site is positively encouraged, provided credit for the article is clearly given to Play the Game and the articles author, as well as a link to is included with copied material. For extensive or professional use of material on, or if you are in doubt about copyright restrictions, please contact us at to confirm permissions. Opinions expressed on this site are the opnions of the authors themselves, not necessarily of Play the Game. Please see site disclaimer for more information.
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Urologia. 2013 Dec 23;804:307-16. doi: 10.5301/uro.5000021. Epub 2013 Jul 26. Italian.
Tadalafil treatment had a modest effect on endothelial cell damage and repair ability markers in men with erectile dysfunction and vascular risk.
Pelliccione F, DAngeli A, DAndrea S, Barbonetti A, Pezzella A, Necozione S, Falone S, Amicarelli F, Francavilla F, Francavilla S.
Asian J Androl. 2013 Dec 23. doi: 10.4103/1008-682X.122347. Epub ahead of print
Evaluation of Tadalafil Nanosuspensions and Their PEG Solid Dispersion Matrices for Enhancing Its Dissolution Properties.
AAPS PharmSciTech. 2014 Jan 9. Epub ahead of print
The use of a single daily dose of tadalafil to treat signs and symptoms of benign prostatic hyperplasia and erectile dysfunction.
Gacci M, Salvi M, Sebastianelli A, Vignozzi L, Corona G, McVary KT, Kaplan SA, Maggi M, Carini M, Oelke M.
Res Rep Urol. 2013 Apr 6;5:99-111. doi: 10.2147/RRU. S31580.
Efficacy and safety of long-term tadalafil 5Pmg once daily combined with sildenafil 50Pmg as needed at the early stage of treatment for patients with erectile dysfunction.
Cui H, Liu B, Song Z, Fang J, Deng Y, Zhang S, Wang H, Wang Z.
Andrologia. 2014 Jan 6. doi: 10.1111/and.12216. Epub ahead of print
Expert Opin Drug Saf. 2014 Jan 3. Epub ahead of print
Tadalafil for erectile dysfunction associated with cardiovascular diseases.
Zhonghua Nan Ke Xue. 2013 Sep;199:860-3. Chinese.
Mohee A, Bretsztajn L, Storey A, Eardley I.
J Sex Med. 2014 Jan 2. doi: 10.1111/jsm.12424. Epub ahead of print
Serum High-Sensitivity C-Reactive Protein Levels and Response to 5 mg Tadalafil Once Daily in Patients With Erectile Dysfunction and Diabetes.
Korean J Urol. 2013 Dec;5412:858-64. doi: 10.4111/kju.2013.54.12.858. Epub 2013 Dec 10.
Naccarato AM, Reis LO, Zani EL, Cartapatti M, Denardi F.
Actas Urol Esp. 2013 Dec 19. pii: S0210-48061300386-0. doi: 2013.10.012. Epub ahead of print English, Spanish.
Tadalafil - a therapeutic option in the management of BPH-LUTS.
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